MAPK14

mitogen-activated protein kinase 14

Ensembl:
ENSG00000112062
UniProt:
Q16539
OMIM:
600289
Synonyms:
CSBP1, CSBP2, CSPB1, MXI2, P38

Cilia effects upon perturbation of MAPK14

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.08) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.16) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

autophagosomes, cilia, cytosol, microtubules, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • ECM & connective tissue
  • Transcription regulation

Function

Upon FGF10 stimulation, the activated FGFR2 initiates the downstream sig ling by phosphorylation (p) of FRS2, MEK1, ERK1/2, and p38(MAPK14 ) within the cilium, which results in transcription of the target genes(40257378).