MAPK15

Cilia effects upon perturbation of MAPK15

Loss-of-function effect:

Decreased cilia number

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

decreased fasting circulating glucose level, hyperactivity, abnormal coat/hair pigmentation, increased mean corpuscular hemoglobin concentration, abnormal startle reflex, decreased locomotor activity

Subcellular localization

basal body, nucleus

References: PMID:29021280, PMID:25823377

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Cell migration & adhesion

Function

Regulates motile and primary cilia formation, and the localisation of ciliary proteins involved in cilium structure, signaling and trasport like BBS7 and ARL-13 (29021280). Required for basal body migration and apical actin organisation in multiciliated cells, it is also important for left-right axis specification. Phosphorylates CapZIP, in cooperation with Dishevelled (25823377).