MAPK15

mitogen-activated protein kinase 15

Ensembl:
ENSG00000181085, ENSG00000274205
UniProt:
Q8TD08
OMIM:
618616
Synonyms:
ERK7, ERK8

Cilia effects upon perturbation of MAPK15

Loss-of-function effect:
Decreased cilia number

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased fasting circulating glucose level, hyperactivity, abnormal coat/hair pigmentation, increased mean corpuscular hemoglobin concentration, abnormal startle reflex, decreased locomotor activity

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion

Function

Regulates motile and primary cilia formation, and the localisation of ciliary proteins involved in cilium structure, sig ling and trasport like BBS7 and ARL-13 (29021280). Required for basal body migration and apical actin organisation in multiciliated cells, it is also important for left-right axis specification. Phosphorylates CapZIP, in cooperation with Dishevelled (25823377).

Model organism evidence

C. elegans (3 references)

We identify several new mutations in genes encoding proteins functioning in intraflagellar transport and cilia assembly, in components of BBSome, MAPK-15, and DYF-5 kinases.

Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells.

PMIDs: 39854273, 29021280, 28745435

Mus musculus (1 reference)

MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis.

PMIDs: 34638386