MAPK6

mitogen-activated protein kinase 6

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000069956
UniProt:
Q16659
Synonyms:
ERK3, HST17250, P97MAPK, PRKM6

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.18) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.12) PMID:41160700

Phenotypes

Mouse phenotype:
anophthalmia, abnormal placenta morphology, no spontaneous movement, edema, decreased brain size, abnormal eye morphology, preweaning lethality, incomplete penetrance, increased startle reflex

Subcellular localization

cilia, nucleus

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

MAPK6 has localized in primary cilia.