MAPKAPK2

MAPK activated protein kinase 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000162889
UniProt:: P49137
OMIM:: 602006
Synonyms:: MK2

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.00) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: increased circulating glucose level, abnormal optic disk morphology, increased large unstained cell number, abnormal clavicle morphology, increased leukocyte cell number, abnormal bone structure, increased eosinophil cell number, abnormal joint morphology

Subcellular localization

basal body, centrosome, cytosol, nucleus

References: PMID:41005307

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

MAPKAPK2 has localized in basal body.

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