MAPKAPK2

MAPK activated protein kinase 2

Ensembl:
ENSG00000162889
UniProt:
P49137
OMIM:
602006
Synonyms:
MK2

Cilia effects upon perturbation of MAPKAPK2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.00) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased circulating glucose level, abnormal optic disk morphology, increased large unstained cell number, abnormal clavicle morphology, increased leukocyte cell number, abnormal bone structure, increased eosinophil cell number, abnormal joint morphology

Subcellular localization

basal body, centrosome, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

MAPKAPK2 has localized in basal body.