MAPRE1

microtubule associated protein RP/EB family member 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000101367
UniProt:: Q15691
OMIM:: 603108
Synonyms:: EB1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centrosome, cytosol, microtubules

References: PMID:41005307, PMID:21768326, PMID:17600711

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Protein processing & maturation

Function

Also known as EB1. Required for assembly of primary cilia, interacting with proteins implicated in microtubule minus-end anchoring at the centrosome to facilitate vesicular trafficking to the cilia base (21768326, 17600711).

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