MAPRE1

microtubule associated protein RP/EB family member 1

Ensembl:
ENSG00000101367
UniProt:
Q15691
OMIM:
603108
Synonyms:
EB1

Cilia effects upon perturbation of MAPRE1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centrosome, cytosol, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

Also known as EB1. Required for assembly of primary cilia, interacting with proteins implicated in microtubule minus-end anchoring at the centrosome to facilitate vesicular trafficking to the cilia base (21768326, 17600711).

Model organism evidence

C. elegans (1 reference)

The diverse morphologies of primary cilia are tightly regulated as a function of cell type and cellular state.

PMIDs: 30955935