MAPRE3

microtubule associated protein RP/EB family member 3

Ensembl:
ENSG00000084764
UniProt:
Q9UPY8
OMIM:
605788
Synonyms:
EB3, RP3

Cilia effects upon perturbation of MAPRE3

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.21) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.77) PMID:41160700

Phenotypes

Mouse phenotype:
decreased leukocyte cell number, increased total body fat amount, preweaning lethality, incomplete penetrance

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

AIPL1 and the EB proteins, EB1 and EB3, localize at the connecting cilia of reti l photoreceptor cells, but do not co-localize in the cellular microtubule network or in cilia in non-reti l cells (25799540).

Model organism evidence

C. elegans (1 reference)

The diverse morphologies of primary cilia are tightly regulated as a function of cell type and cellular state.

PMIDs: 30955935