MAPT

microtubule associated protein tau

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000186868
UniProt:
P10636
OMIM:
157140
Synonyms:
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, TAU-40, TAU-PHF6

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.47) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased fluid intake, decreased exploration in new environment, decreased total reti thickness, decreased grip strength

Subcellular localization

cytosol, flagella, microtubules, nucleus

References: PMID:25613900

Functional category

  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

MAPT localized to flagella (25613900)