MAPT
microtubule associated protein tau
- Ensembl:
- ENSG00000186868, ENSG00000276155, ENSG00000277956
- UniProt:
- P10636
- OMIM:
- 157140
- Synonyms:
- DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549
Cilia effects upon perturbation of MAPT
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.47) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- increased fluid intake, decreased exploration in new environment, decreased total reti thickness, decreased grip strength
- Mouse ciliopathy phenotype:
- abnormal reti blood vessel morphology, polycystic kidney, persistence of hyaloid vascular system, abnormal reti vasculature morphology
Subcellular localization
cytosol, flagella, microtubules, nucleus
Functional category
- Actin & cytoskeleton regulation
- Neurogenesis & migration
- Viral interactions
- Protein processing & maturation
- Signaling (Hedgehog, GPCRs, ion channels)
Function
MAPT localized to flagella (25613900)