MARCHF7

membrane associated ring-CH-type finger 7

Ensembl:
ENSG00000136536
UniProt:
Q9H992
OMIM:
613334
Synonyms:
AXOT, MARCH-VII, MARCH7, RNF177

Cilia effects upon perturbation of MARCHF7

Ciliogenesis screen results (1 screen)

  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.50, ciliated=56.7%) PMID:26595381

Phenotypes

Mouse phenotype:
increased prepulse inhibition, increased startle reflex

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Cell migration & adhesion

Function

E3 ubiquitin ligase, works with USP9X to ubiquiti te NPHP5 and regulate ciliogenesis (28498859).