MARCKS

myristoylated alanine rich protein kinase C substrate

Ensembl:: ENSG00000277443
UniProt:: P29966
OMIM:: 177061
Synonyms:: 80K-L, MACS, PKCSL

Cilia effects upon perturbation of MARCKS

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: abnormal coat appearance, decreased circulating aspartate transamise level

Subcellular localization

centrosome, cilia, nucleus

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Metabolism

Function

Loss of Marcks blocks the targeting of CDC42 to ciliogenesis sites, thereby impairing the vesicular transport essential for cilium assembly. As a result, cells exhibit either absent or shortened cilia., MARCKS has localized in primary cilia.

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