MARK4

microtubule affinity regulating kinase 4

Ensembl:
ENSG00000007047
UniProt:
Q96L34
OMIM:
606495
Synonyms:
FLJ90097, KIAA1860, MARKL1, NBLA00650, PAR-1D

Cilia effects upon perturbation of MARK4

Loss-of-function effect:
Impaired ciliogenesis

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.40) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased vertical activity, abnormal skin morphology, abnormal spleen morphology, granulomatous inflammation, abnormal eye morphology, chronic inflammation, enlarged spleen
Mouse ciliopathy phenotype:
microphthalmia, small testis, abnormal uterus morphology

Subcellular localization

basal body, centrosome, cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Required for initiation of axoneme extension during early ciliogenesis, after the docking of Rab8a-positive vesicles to the mother centriole. Regulates ODF2 localisation to the centriole (23400999).

Model organism evidence

Mus musculus (1 reference)

The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.

PMIDs: 23400999