MARK4

microtubule affinity regulating kinase 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000007047
UniProt:
Q96L34
OMIM:
606495
Synonyms:
FLJ90097, KIAA1860, MARKL1, NBLA00650, PAR-1D

Cilia effects upon perturbation of MARK4

Loss-of-function effect:
Impaired ciliogenesis

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.40) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased vertical activity, abnormal skin morphology, abnormal spleen morphology, granulomatous inflammation, abnormal eye morphology, chronic inflammation, enlarged spleen

Subcellular localization

basal body, centrosome, cilia

References: PMID:23400999

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Required for initiation of axoneme extension during early ciliogenesis, after the docking of Rab8a-positive vesicles to the mother centriole. Regulates ODF2 localisation to the centriole (23400999).