MAS1

MAS1 proto-oncogene, G protein-coupled receptor

Ensembl:
ENSG00000130368
UniProt:
P04201
OMIM:
165180

Cilia effects upon perturbation of MAS1

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.14) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.67) PMID:41160700

Phenotypes

Mouse phenotype:
increased bone mineral content, abnormal bone structure
Mouse ciliopathy phenotype:
short tibia

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Neuro l ciliary GPCR. Galanin receptor.