?

Phenotypes

Mouse phenotype:

abnormal brain morphology, abnormal testis morphology, enlarged testis, cataract, abnormal vitreous body morphology

Subcellular localization

cilia, Plasma membrane

Functional category

• Small GTPases
• Non-motile cilium / primary cilium
• Signaling (Hedgehog
• GPCRs
• ion channels)

Function

MC5R localizes to the primary cilium in IMCD3 cells, and MRAP2 promotes its enrichment within the ciliary compartment(36512344).