MCC

MCC regulator of WNT signaling pathway

Ensembl:
ENSG00000171444
UniProt:
P23508
OMIM:
159350

Cilia effects upon perturbation of MCC

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.87) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Cell migration & adhesion

Function

When overexpressed, MCC has been shown to bind 尾-catenin (CTNNB1) in the nucleus to negatively regulate canonical WNT sig ling in cancer cell lines and to inhibit cell proliferation (18591935, 24824780). MCC colocalized with PCNT at pericentriolar material (PCM) and colocalized with NINEIN, CEP170, NDE1, CEP131, and NHERF1 at the centrosome. MCC is a centrosomal protein that relocalizes to non-centrosomal apical sites during intesti l cell differentiation (36217793).

Model organism evidence

Xenopus (1 reference)

Multiciliated cells (MCCs) are essential for generating directional fluid flow across specialized epithelia in various vertebrate organs.

PMIDs: 41705999

Mus musculus (1 reference)

Notably, expression of caveolin-1 (Cav-1) has been linked to specific cell types within the airway epithelium, primarily basal stem cells (BSCs) and multiciliated cells (MCCs).

PMIDs: 41692788