MCC

MCC regulator of WNT signaling pathway

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000171444
UniProt:: P23508
OMIM:: 159350

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.87) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, nucleus

References: PMID:36217793

Functional category

Ciliary assembly/disassembly
Cell migration & adhesion

Function

When overexpressed, MCC has been shown to bind β-catenin (CTNNB1) in the nucleus to negatively regulate canonical WNT signaling in cancer cell lines and to inhibit cell proliferation (18591935, 24824780). MCC colocalized with PCNT at pericentriolar material (PCM) and colocalized with NINEIN, CEP170, NDE1, CEP131, and NHERF1 at the centrosome. MCC is a centrosomal protein that relocalizes to non-centrosomal apical sites during intestinal cell differentiation (36217793).

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