MCHR1

melanin concentrating hormone receptor 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000128285
UniProt:
Q99705
OMIM:
601751
Synonyms:
GPR24, MCH1R, SLC1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.81) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia, lysosomes

References: PMID:32240710, PMID:18256283

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane

Function

Involved in the primary cilia shortening through a unique signal from the ciliary membrane (32240710). Candidate ciliary GPCR (18256283).