MCHR1

melanin concentrating hormone receptor 1

Ensembl:
ENSG00000128285
UniProt:
Q99705
OMIM:
601751
Synonyms:
GPR24, MCH1R, SLC1

Cilia effects upon perturbation of MCHR1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.81) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia, lysosomes

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane

Function

Involved in the primary cilia shortening through a unique sig l from the ciliary membrane (32240710). Candidate ciliary GPCR (18256283).

Model organism evidence

Mus musculus (2 references)

We found that melanin-concentrating hormone receptor 1 (MCHR1) was predominantly expressed in FrA primary cilia, and restraint stress upregulated MCH expression.

The Transition Zone Protein AHI1 Regulates Neuronal Ciliary Trafficking of MCHR1 and Its Downstream Signaling Pathway.

PMIDs: 40203655, 33741721

C. elegans (1 reference)

Primary cilia are cellular appendages critical for diverse types of Signaling.

PMIDs: 36849261