MCIDAS
multiciliate differentiation and DNA synthesis associated cell cycle protein
- Ensembl:
- ENSG00000234602
- UniProt:
- D6RGH6
- OMIM:
- 614086
- Synonyms:
- IDAS, MCI, MCIN
Cilia effects upon perturbation of MCIDAS
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
Ciliogenesis screen results (1 screen)
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- atrophy, abnormal spleen morphology, decreased lean body mass, increased vertical activity, increased grip strength, rhinitis, hypospermia, inflammation, developmental dysplasia, decreased prepulse inhibition, ciliary motility defect, spermatogenesis defect, decreased startle reflex, increased leukocyte cell number, increased circulating total protein level
- Mouse ciliopathy phenotype:
- abnormal auditory brainstem response, increased circulating alanine transamise level, hydrocephalus, male infertility, female infertility
- Human ciliopathy phenotype:
- primary ciliary dyskinesia
Ciliopathy associations
- Mucociliary Clearance Disorder
- Primary Ciliary Dyskinesia
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Cell migration & adhesion
Function
Promotes multiciliated cell formation during multiciliate cell differentiation. Mutations lead to severe axonemal defects, lack of ciliary motility- related proteins (25048963). Promotes the transcriptio l changes required for motile ciliogenesis and centriole assembly, it induces motile cilia outgrowth via FoxJ1, centriole assembly and basal body formation. Regulates the genes required for multiciliated cells differentiation (22231168, 26933123).