MCIDAS
multiciliate differentiation and DNA synthesis associated cell cycle protein
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000234602
- UniProt:
- D6RGH6
- OMIM:
- 614086
- Synonyms:
- IDAS, MCI, MCIN
Cilia effects upon perturbation of MCIDAS
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
Ciliogenesis screen results (1 screens)
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- atrophy, abnormal spleen morphology, decreased lean body mass, increased vertical activity, increased grip strength, rhinitis, hypospermia, inflammation, developmental dysplasia, decreased prepulse inhibition, ciliary motility defect, spermatogenesis defect, decreased startle reflex, increased leukocyte cell number, increased circulating total protein level
- Human ciliopathy phenotype:
- primary ciliary dyskinesia
Ciliopathy associations
- Mucociliary Clearance Disorder
- Primary Ciliary Dyskinesia
References: PMID:25048963, PMID:26777464, PMID:26395491
Subcellular localization
cilia
References: PMID:25048963, PMID:22231168, PMID:26933123
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Cell migration & adhesion
Function
Promotes multiciliated cell formation during multiciliate cell differentiation. Mutations lead to severe axonemal defects, lack of ciliary motility- related proteins (25048963). Promotes the transcriptional changes required for motile ciliogenesis and centriole assembly, it induces motile cilia outgrowth via FoxJ1, centriole assembly and basal body formation. Regulates the genes required for multiciliated cells differentiation (22231168, 26933123).