MCM2

minichromosome maintenance complex component 2

Ensembl:
ENSG00000073111
UniProt:
P49736
OMIM:
116945
Synonyms:
BM28, CCNL1, CDC19, CDCL1, D3S3194

Cilia effects upon perturbation of MCM2

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Shorter cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.66) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.14) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Subcellular localization

basal body, cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Transcription regulation
  • Cilia length regulation

Function

Function in transcriptio l regulation/inhibition of genes involved in ciliogenesis and centrosome duplication. Helps to control left-right asymmetry development in zebrafish, facilitates formation and hence proper function of motile and primary cilia. Likely controls cilia length . Loss of MCM2 promotes transcription of a subset of genes, which cause cilia shortening and centriole overduplication (30329080).

Model organism evidence

Danio rerio (1 reference)

Zebrafish depleted of MCM2 develop ciliopathy-phenotypes including microcephaly and aberrant heart looping due to malformed cilia.

PMIDs: 30329080