MCM7
minichromosome maintenance complex component 7
- Ensembl:
- ENSG00000166508
- UniProt:
- P33993
- OMIM:
- 600592
- Synonyms:
- CDC47, MCM2, PPP1R104
Cilia effects upon perturbation of MCM7
- Cilia number / % ciliated:
- Unknown
- Loss-of-function effect:
- Supernumerary cilia
- Overexpression effect:
- Unknown
Ciliogenesis screen results (5 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.65) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
- Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Candidate (Z2MCilia=1.99) PMID:37771269
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.23) PMID:41160700
Phenotypes
- Human ciliopathy phenotype:
- Severe intellectual disability and progressive spastic paraplegia
Subcellular localization
cilia, cytosol, nucleus
Functional category
- Ciliary assembly/disassembly
- Metabolism
Function
MCM7 has localized in cilia. Loss of MCM7 gene cause supernumerary cilia(PMID: 37771269).
Model organism evidence
Danio rerio (1 reference)
Zebrafish depleted of MCM2 develop ciliopathy-phenotypes including microcephaly and aberrant heart looping due to malformed cilia.
PMIDs: 30329080