MCM7

minichromosome maintenance complex component 7

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000166508
UniProt:
P33993
OMIM:
600592
Synonyms:
CDC47, MCM2, PPP1R104

Cilia effects upon perturbation of MCM7

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Supernumerary cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (5 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.65) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Candidate (Z2MCilia=1.99) PMID:37771269
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.23) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
Severe intellectual disability and progressive spastic paraplegia

Subcellular localization

cilia, cytosol, nucleus, basal body

References: PMID:41410385, PMID:41005307, PMID:37771269

Functional category

  • Ciliary assembly/disassembly
  • Metabolism

Function

MCM7 has localized in cilia. Loss of MCM7 gene cause supernumerary cilia(PMID: 37771269).