MDH1B

malate dehydrogenase 1B

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000138400
UniProt:: Q5I0G3
Synonyms:: FLJ25341, RP11-95H11

Ciliogenesis screen results (1 screens)

Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.04, ciliated=53.3%) PMID:26595381

Phenotypes

Mouse phenotype:: abnormal retina inner nuclear layer morphology

Subcellular localization

cilia

References: PMID:42010243, PMID:39743588

Function

MDH1B has localized in ciliary tip. Identified by cryo-EM as a component of radial spoke 3 in sperm flagella and other motile cilia (Leung et al., 2025, Nature, PMID 39743588).

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