MDM2

MDM2 proto-oncogene

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000135679
UniProt:: Q00987
OMIM:: 164785
Synonyms:: MGC5370, HDM2

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.06) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centriolar satellites, cilia, cytosol, end piece, mid piece, nucleoplasm, principal piece

References: PMID:41410385

Function

MDM2, which localized to the RL of the cilia in all five tissues and showed a strong concordance between image observation and image analysis results. MDM2 has located to motile cilia.

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