MDM2

MDM2 proto-oncogene

Ensembl:: ENSG00000135679
UniProt:: Q00987
OMIM:: 164785
Synonyms:: MGC5370, HDM2

Cilia effects upon perturbation of MDM2

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.06) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centriolar satellites, cilia, cytosol, end piece, mid piece, nucleoplasm, principal piece

Function

MDM2, which localized to the RL of the cilia in all five tissues and showed a strong concordance between image observation and image analysis results. MDM2 has located to motile cilia.

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