MECOM

MDS1 and EVI1 complex locus

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000085276
UniProt:: Q03112
OMIM:: 165215
Synonyms:: EVI1, KMT8E, MDS1, MDS1-EVI1, PRDM3

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal locomotor activation, decreased prepulse inhibition, thrombocytopenia, increased blood urea nitrogen level, limb grasping, increased startle reflex, increased circulating amylase level, increased lean body mass, preweaning lethality, complete penetrance, decreased hemoglobin content, abnormal startle reflex, decreased erythrocyte cell number

Subcellular localization

nucleus

References: PMID:24309209

Functional category

Ciliary assembly/disassembly

Function

Mecom and Notch controls nephron multiciliated cell (MCC) fate, retinoic acid (RA) negatively regulates mecom in renal progenitors to promote MCC formation, and mecom attenuates MCC number by positively regulating Notch activity downstream of RA ( 24309209).

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