MEGF10

multiple EGF like domains 10

Ensembl:
ENSG00000145794
UniProt:
Q96KG7
OMIM:
612453
Synonyms:
KIAA1780, SR-F3, EMARDD, CMYO10A, CMYO10B

Cilia effects upon perturbation of MEGF10

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Unknown
Overexpression effect:
Unknown

Ciliogenesis screen results (1 screen)

  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.20) PMID:41160700

Phenotypes

Mouse phenotype:
abnormal retina mosaic patterning of starburst amacrine cells; muscle satellite cell defects

Subcellular localization

cilia, plasma membrane

Functional category

  • Phagocytic receptor
  • Cell-cell adhesion
  • Cilium-derived extracellular vesicles

Function

Single-pass transmembrane phagocytic receptor with N-terminal EMI domain followed by 17 atypical EGF-like extracellular repeats and cytoplasmic NPxY/YxxL motifs. Mammalian ortholog of C. elegans CED-1 and Drosophila Draper. Established mammalian functions: engulfing-cell receptor for apoptotic corpses (binding C1q and phosphatidylserine eat-me signal); regulator of skeletal muscle satellite cell proliferation/differentiation via Notch signaling; mediator of mosaic spacing of starburst amacrine cells in retina via homotypic neuron repulsion; uptake of amyloid-beta peptides in brain. C. elegans CED-1 localizes to dendrites and primary cilia of male tail RnB sensory neurons, where loss of ced-1 reduces ciliary abundance of PKD-2 and CLHM-1 ion channels and reduces extracellular vesicle shedding from the cilium distal tip in response to mating partners (Ke and Tanis 2025, bioRxiv 10.1101/2025.09.15.676301). Mammalian ciliary role not yet directly demonstrated; preprint authors speculate conserved function.

Model organism evidence

C. elegans (1 reference)

C. elegans CED-1::mNG localizes to dendrites and the ciliary region of B-type ray sensory neurons (Ke & Tanis 2025).

Loss of ced-1 reduces ciliary abundance of PKD-2 and CLHM-1 ion channels and reduces extracellular vesicle shedding from the cilium distal tip in response to mating partners.

PMIDs: PMC12670632

Mus musculus (0 references)

Megf10 knockout: abnormal retina mosaic patterning of starburst amacrine cells; muscle satellite cell defects. Direct ciliary phenotype not yet reported in mouse.