MIB1

MIB E3 ubiquitin protein ligase 1

Ensembl:
ENSG00000101752
UniProt:
Q86YT6
OMIM:
608677
Synonyms:
DIP-1, KIAA1323, MIB, ZZANK2, ZZZ6

Cilia effects upon perturbation of MIB1

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Suppressed ciliogenesis

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-2.05) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centrosome, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Interacts with and ubiquitylates AZI1 and PCM1, regulates the composition and function of centriolar satellites and suppresses primary ciliogenesis (24121310). MIB1 destabilizes Talpid3 through poly- ubiquitylation and suppresses cilium assembly (27146717). It redistributes to centrioles in response to conditions that induce centriole amplification, interacts with Plk4 and promotes its ubiquitylation, which is important for centriole homeostasis (25795303).