MICAL3

microtubule associated monooxygenase, calponin and LIM domain containing 3

Ensembl:: ENSG00000243156
UniProt:: Q7RTP6
OMIM:: 608882
Synonyms:: KIAA0819

Cilia effects upon perturbation of MICAL3

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.70) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal coat/hair pigmentation, increased mean corpuscular hemoglobin, increased leukocyte cell number, abnormal vocalization, hyperactivity
Mouse ciliopathy phenotype:: abnormal auditory brainstem response

Subcellular localization

basal body, nucleus

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

CC2D2A provides a docking point at the photoreceptor ciliary base, allowing RAB8A-positive vesicles to bind through a series of interactions involving CC2D2A-NINL-MICAL3-RAB8A , a chain of physical interactions linking CC2D2A to RAB8A through NINL and MICAL3(26485645).

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