MIF

macrophage migration inhibitory factor

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000240972
UniProt:
P14174
OMIM:
153620
Synonyms:
GIF, GLIF

Cilia effects upon perturbation of MIF

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.64) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Subcellular localization

basal body

References: PMID:38052787

Functional category

  • Ciliary assembly/disassembly
  • Cell migration & adhesion
  • Transcription regulation

Function

Macrophage migration inhibitory factor (MIF) is a structure protein of basal bodies, which forms a ring-like structure at proximal end of centrioles to regulate cilia assembly and elongation through defined ciliary proteins, including CP110, TTBK2, CEP290, and IFT related proteins, The phosphatidylinositol-5-phosphate 4-kinase type 2 alpha (PIP4K2a) is an upstream regulator of MIF, which interacts and phosphorylates MIF at S91 to increase the interaction of MIF with 14-3-3ΞΆ, resulting in MIF nuclear translocation. Nuclear MIF functions to regulate the transcription of ciliary related genes(38052787).