MIF

macrophage migration inhibitory factor

Ensembl:
ENSG00000240972, ENSG00000276701
UniProt:
P14174
OMIM:
153620
Synonyms:
GIF, GLIF

Cilia effects upon perturbation of MIF

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.64) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Cell migration & adhesion
  • Transcription regulation

Function

Macrophage migration inhibitory factor (MIF) is a structure protein of basal bodies, which forms a ring-like structure at proximal end of centrioles to regulate cilia assembly and elongation through defined ciliary proteins, including CP110, TTBK2, CEP290, and IFT related proteins, The phosphatidylinositol-5-phosphate 4-ki se type 2 alpha (PIP4K2a) is an upstream regulator of MIF, which interacts and phosphorylates MIF at S91 to increase the interaction of MIF with 14-3-3味, resulting in MIF nuclear translocation. Nuclear MIF functions to regulate the transcription of ciliary related genes(38052787).

Model organism evidence

Mus musculus (1 reference)

Relative to wild-type, the hfq mutant had reduced motility, fewer flagella and less hemolysin expression and was less prone to form biofilm and to adhere to and invade uroepithelial cells.

PMIDs: 24454905