MIR34B

microRNA 34b

Ensembl:: ENSG00000207811
OMIM:: 611374
Synonyms:: HSA-MIR-34B, MIRN34B

Cilia effects upon perturbation of MIR34B

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Subcellular localization

cilia associated gene

Functional category

Ciliary assembly/disassembly
Reproduction & sperm
Cardiac & muscle development

Function

Required for the multiciliogenesis of multiciliated cells in the kidney and olfactory placode. It plays essential roles in the formation and organisation of cilia bundles. Serves as a guardian to maintain optimal levels of cmyb ( 23698347). Essential for normal brain development, motile ciliogenesis, and spermatogenesis ( 24982181).

Model organism evidence

Mus musculus (1 reference)

The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis.

PMIDs: 37102425

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