MIR449A

microRNA 449a

Ensembl:: ENSG00000198983
OMIM:: 613131
Synonyms:: HSA-MIR-449, HSA-MIR-449A, MIRN449, MIRN449A

Cilia effects upon perturbation of MIR449A

Subcellular localization

cilia associated

Functional category

Ciliary assembly/disassembly
Cilia???cytoskeleton/adhesion links

Function

Simultaneous inactivation of two functionally related miRNA clusters (miR-34b/c and miR-449) encoding five miRNAs (miR-34b, miR-34c, miR-449a, miR-449b, and miR-449c) led to sexually dimorphic, partial perinatal lethality, growth retardation, and infertility. These developmental defects correlated with the dysregulation of ∼ 240 target genes, which are mainly involved in three major cellular functions, including cell-fate control, brain development and microtubule dynamics. Our data demonstrate an essential role of a miRNA family in brain development, motile ciliogenesis, and spermatogenesis(24982181).

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