MMP13

Cilia effects upon perturbation of MMP13

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.01) PMID:41160700

Phenotypes

Mouse phenotype:

prolonged qt interval, abnormal thymus morphology, decreased heart rate, enlarged spleen, enlarged thymus, abnormal spleen morphology, increased circulating alkaline phosphatase level, prolonged rr interval, decreased circulating sodium level

Mouse ciliopathy phenotype:

short tibia

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly
• Metabolism
• Signaling (Hedgehog, GPCRs, ion channels)
• ECM & connective tissue
• Transcription regulation

Function

CITED2 is a critical mediator in the sig ling generated by strain and transduced by primary cilia, extracellular ATP-induced purinergic receptors and calcium sig ling, that leads to transactivation of CITED2. Strain-induced CITED2 transactivation requires HIF1α and Sp1 and intact SSRE and leads to the downregulation of MMP (Mmp1, and of Mmp13)expression( 26687824).

Model organism evidence