MMP14

matrix metallopeptidase 14

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000157227
UniProt:
P50281
OMIM:
600754
Synonyms:
MT1-MMP

Cilia effects upon perturbation of MMP14

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:32229724

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation
  • Cell migration & adhesion
  • Cardiac & muscle development

Function

MT1-MMP(MMP14) is required for ciliogenesis and EC maturation through suppression of Notch signaling during early brain development. MT1-MMP is critical for early brain development and loss of MT1-MMP activity gives rise to hydrocephalus ( 32229724).