MMP21

matrix metallopeptidase 21

Ensembl:
ENSG00000154485
UniProt:
Q8N119
OMIM:
608416

Cilia effects upon perturbation of MMP21

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.39) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
visceral heterotaxy

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly

Function

Known to cause heterotaxy and primary ciliary dyskinesia (30622330). Specialised role in the generation of left-right asymmetry (26437028).