MMP7

matrix metallopeptidase 7

Ensembl:
ENSG00000137673
UniProt:
P09237
OMIM:
178990
Synonyms:
MPSL1, PUMP-1

Cilia effects upon perturbation of MMP7

Cilia number / % ciliated:
Incrased cilia number

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

MMP7 regulated ciliated cell formation, the recovery of the airway epithelium in wild-type and Mmp7-null mice in vivo after phthalene injury, which revealed augmented ciliated cell formation in the absence of MMP7 ( 23258229).

Model organism evidence

Mus musculus (1 reference)

Matrix metalloproteinase 7 (MMP7) regulates of ciliogenesis and is a biomarker for idiopathic pulmonary fibrosis (IPF) in humans.

PMIDs: 35204783