MMP7

matrix metallopeptidase 7

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000137673
UniProt:: P09237
OMIM:: 178990
Synonyms:: MPSL1, PUMP-1

Cilia effects upon perturbation of MMP7

Cilia number / % ciliated:: Incrased cilia number

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:23258229

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

MMP7 regulated ciliated cell formation, the recovery of the airway epithelium in wild-type and Mmp7-null mice in vivo after phthalene injury, which revealed augmented ciliated cell formation in the absence of MMP7 ( 23258229).

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