MOK
MOK protein kinase
- Ensembl:
- ENSG00000080823
- UniProt:
- Q9UQ07
- OMIM:
- 605762
- Synonyms:
- RAGE, RAGE1, STK30
Cilia effects upon perturbation of MOK
- Cilia number / % ciliated:
- No effect
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- No effect
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- abnormal behavior, decreased grip strength
Subcellular localization
basal body
Functional category
- Ciliary assembly/disassembly
Function
Negative regulattion of cilium length through the inhibition of the mTORC1 pathway and suppressing the synthesis of ciliary tubulin. It is part of, or transported by the IFT machinery (25243405).
Model organism evidence
C. elegans (1 reference)
Disruption of cilia structure or function leads to a diverse collection of diseases termed ciliopathies.1-3 The highly conserved CCRK and RCK kinases (ICK/MOK/MAK) negatively regulate cilia length and structure in Chlamydomonas, C.
PMIDs: 34731674
Mus musculus (1 reference)
Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells.
PMIDs: 25243405