MOK

MOK protein kinase

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000080823
UniProt:: Q9UQ07
OMIM:: 605762
Synonyms:: RAGE, RAGE1, STK30

Cilia effects upon perturbation of MOK

Cilia number / % ciliated:: No effect
Loss-of-function effect:: Longer cilia
Overexpression effect:: No effect

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal behavior, decreased grip strength

Subcellular localization

basal body

References: PMID:25243405

Functional category

Ciliary assembly/disassembly

Function

Negative regulattion of cilium length through the inhibition of the mTORC1 pathway and suppressing the synthesis of ciliary tubulin. It is part of, or transported by the IFT machinery (25243405).

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