MORN5

MORN repeat containing 5

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000185681
UniProt:: Q5VZ52
OMIM:: 619837
Synonyms:: C9ORF113, C9ORF18, FLJ46909

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body

References: PMID:28742876, PMID:39743588

Functional category

Ciliary assembly/disassembly
Reproduction & sperm

Function

Associated with cytoskeletal structures in the sperm flagellum. Function in signaling during sperm development (28742876). Identified by cryo-EM as a component of radial spoke 3 in sperm flagella and other motile cilia (Leung et al., 2025, Nature, PMID 39743588).

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