MPHOSPH9

Cilia effects upon perturbation of MPHOSPH9

Cilia number / % ciliated:

Incrased cilia number

Loss-of-function effect:

Longer cilia

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.43) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

increased prepulse inhibition, increased circulating amylase level

Subcellular localization

basal body, centrosome

Functional category

• Ciliary assembly/disassembly

Function

Forms a ring-like structure and regulates ciliogenesis by modulating CP110-CEP97 complex recruitment and localization at the mother centriole, by directly binding CEP97, which blocks cilia assembly in cycling cells able to form cilia. degradation of MPP9 facilitates the removal of the CP110-CEP97 complex from basal bodies and promotes cilia formation (30375385).