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Subcellular localization

cilia

Functional category

• Motile cilium & axoneme
• Non-motile cilium / primary cilium
• Cilia–cytoskeleton/adhesion links

Function

The G protein-coupled receptor melanocortin-4 receptor (MC4R) and its associated protein melanocortin receptor-associated protein 2 (MRAP2) are essential for the regulation of food intake and body weight in humans. MC4R localizes and functions at the neuronal primary cilium, a microtubule-based organelle that senses and relays extracellular signals. Here, we demonstrate that MRAP2 is critical for the weight-regulating function of MC4R neurons and the ciliary localization of MC4R(36692018).