MS4A8

membrane spanning 4-domains A8

Ensembl:: ENSG00000166959
UniProt:: Q9BY19
OMIM:: 606549
Synonyms:: CD20L5, MS4A4, MS4A8B

Cilia effects upon perturbation of MS4A8

Ciliogenesis screen results (1 screen)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

Function

MS4A8B, a member of the MS4A (membrane-spanning, 4 domains, subfamily A) family, contains a putative immunoreceptor tyrosine-based inhibitory motif (ITIM) and we have previously shown that MS4A8B is expressed on the cilia of airway epithelial cells. MS4A8B gene expression increased over time as PBECs underwent complete mucociliary differentiation( https://doi.org/10.1183/13993003.congress-2015.PA919).MS4A8 is specifically localized to CL of motile ciliated cells across all five tissue types(https://doi.org/10.1101/2025.03.18.643967).MS4A8 has located to motile cilia.

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