MTMR11

Cilia effects upon perturbation of MTMR11

Loss-of-function effect:

Longer cilia

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.06) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

enlarged spleen, enlarged lymph nodes, abnormal semil vesicle morphology, thick skin

Mouse ciliopathy phenotype:

abnormal sternum morphology

Subcellular localization

basal body, lysosomes

Functional category

• Ciliary assembly/disassembly

Function

Mtmr11 and Ankrd45 are similarly uncharacterized and were found specifically at basal bodies(29180514).