MTSS1

Cilia effects upon perturbation of MTSS1

Loss-of-function effect:

Longer cilia

Ciliogenesis screen results (4 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.43) PMID:41160700

Subcellular localization

basal body

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation

Function

MIM is able to bind to the intracellular mediators of Shh sig ling Sufu and Gli and positively regulate the pathway (17497115). MIM is part of a basal body complex required for primary cilia mainte nce and Shh sig ling, and functions by a mechanism that involves antagonism of CTTN phosphorylation by p60 Src ki se. MIM is required in the dermal papilla for primary cilia formation and hair follicle regeneration (20708589).