MUC1

mucin 1, cell surface associated

Ensembl:
ENSG00000185499
UniProt:
P15941
OMIM:
158340
Synonyms:
ADMCKD, ADMCKD1, CA15-3, CD227, EMA

Cilia effects upon perturbation of MUC1

Ciliogenesis screen results (6 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.44) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.64, ciliated=17.4%) PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-3.32) PMID:20393562
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.13) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
tubulointerstitial kidney disease, autosomal dominant, 2; autosomal dominant medullary cystic kidney disease with or without hyperuricemia

Subcellular localization

basal body, cilia, lysosomes, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

MUC1 and MUC4 together in the same preparation showed spatial co-localization in the cell surface regions corresponding to the microvilli of ciliated cells at the base of the cilia (22929560).