MUC20

mucin 20, cell surface associated

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000274843
UniProt:
Q8N307
OMIM:
610360
Synonyms:
FLJ14408, KIAA1359

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.60) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=831, lfc=-2.47) PMID:30270045

Subcellular localization

cilia

References: PMID:22929560

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

It is likely MUC20 is secreted/shed from the epithelium into airway secretions (22929560).