MUC4

mucin 4, cell surface associated

Ensembl:: ENSG00000277585, ENSG00000275164, ENSG00000278303, ENSG00000273822, ENSG00000273984, ENSG00000276613, ENSG00000145113, ENSG00000278468
UniProt:: Q99102
OMIM:: 158372
Synonyms:: ASGP, MUC-4

Cilia effects upon perturbation of MUC4

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.16) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

MUC1 and MUC4 together in the same preparation showed spatial co-localization in the cell surface regions corresponding to the microvilli of ciliated cells at the base of the cilia (22929560).

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