MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
- Ensembl:
- ENSG00000291363, ENSG00000215182
- UniProt:
- P98088
- OMIM:
- 158373
- Synonyms:
- MUC5
Cilia effects upon perturbation of MUC5AC
- Cilia number / % ciliated:
- Incrased cilia number
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.29) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- abnormal skin coloration, preweaning lethality, incomplete penetrance
- Mouse ciliopathy phenotype:
- persistence of hyaloid vascular system
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Signaling (Hedgehog, GPCRs, ion channels)
Function
MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium ( 36427316)