MUC5B

mucin 5B, oligomeric mucus/gel-forming

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000117983
UniProt:: Q9HC84
OMIM:: 600770
Synonyms:: MG1, MUC-5B, MUC5

Cilia effects upon perturbation of MUC5B

Cilia number / % ciliated:: Decreased cilia number

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased prepulse inhibition, abnormal skin morphology, small liver, decreased startle reflex
Human ciliopathy phenotype:: idiopathic pulmonary fibrosis

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:36427316

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium ( 36427316)

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