MUC5B
mucin 5B, oligomeric mucus/gel-forming
- Ensembl:
- ENSG00000117983
- UniProt:
- Q9HC84
- OMIM:
- 600770
- Synonyms:
- MG1, MUC-5B, MUC5
Cilia effects upon perturbation of MUC5B
- Cilia number / % ciliated:
- Decreased cilia number
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- decreased prepulse inhibition, abnormal skin morphology, small liver, decreased startle reflex
- Mouse ciliopathy phenotype:
- abnormal liver morphology
- Human ciliopathy phenotype:
- idiopathic pulmonary fibrosis
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Signaling (Hedgehog, GPCRs, ion channels)
Function
MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium ( 36427316)