MXI1

MAX interactor 1, dimerization protein

Ensembl:
ENSG00000119950
UniProt:
P50539
OMIM:
600020
Synonyms:
BHLHC11, MAD2, MXD2, MXI

Cilia effects upon perturbation of MXI1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.10) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly

Function

Ciliogenesis and Ift20 expression were regulated by Mxi1 in vitro. Mxi1 regulates Ift20 promoter activity via Ets-1 binding to the Ift20 promoter ( 23316056).

Model organism evidence

Mus musculus (1 reference)

Here, we clarified the relationship between Mxi1 inactivation and cilia disassembly.

PMIDs: 23316056