MYB

MYB proto-oncogene, transcription factor

Ensembl:
ENSG00000118513
UniProt:
P10242
OMIM:
189990
Synonyms:
C-MYB

Cilia effects upon perturbation of MYB

Loss-of-function effect:
Delayed multiciliogenesis

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
spi bifida, preweaning lethality, incomplete penetrance, hemorrhage, pallor, edema, abnormal skin appearance

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

Activates endogenous Foxj1 expression, stimulates a cotransfected Foxj1 reporter in heterologous cells and regulates centriole amplification, which in turn activates centriole docking and the assembly of a motile cilium, so it drives a complete multiciliogenesis program (24048590).

Model organism evidence

Xenopus (2 references)

In multiciliated cells (MCCs) of the epidermis, ATP4a was also necessary for normal myb expression, a

Myb promotes centriole amplification and later steps of the multiciliogenesis program.

PMIDs: 25848696, 24048590

Mus musculus (1 reference)

Myb promotes centriole amplification and later steps of the multiciliogenesis program.

PMIDs: 24048590