MYC

MYC proto-oncogene, bHLH transcription factor

Ensembl:
ENSG00000136997
UniProt:
P01106
OMIM:
190080
Synonyms:
BHLHE39, C-MYC, MYCC

Cilia effects upon perturbation of MYC

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.62) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased bone mineral content; preweaning lethality; complete penetrance; decreased fluid intake; decreased bone mineral density; increased startle reflex; decreased prepulse inhibition; increased grip strength; abnormal bone structure; decreased body length

Ciliopathy associations

  • Medulloblastoma

Subcellular localization

cilia associated gene, nucleoplasm

Functional category

  • Motile cilium & axoneme

Function

The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression (PMID: 24349431).