MYCBP
MYC binding protein
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000214114
- UniProt:
- Q99417
- OMIM:
- 606535
- Synonyms:
- AMY-1
Subcellular localization
cilia, axoneme, central apparatus
References: doi:10.7554/eLife.110601
Function
MYCBP (AMY-1), the vertebrate homolog of Chlamydomonas FAP174, is a central-apparatus protein that localizes to the axonemal central lumen of vertebrate motile cilia. It was identified by mass spectrometry in both MYCBPAP and CFAP70 immunoprecipitates and co-immunoprecipitates with MYCBPAP; its ciliary signal is reduced (though still detectable) upon loss of C2a components, suggesting additional axonemal docking sites beyond the C2a projection (Lyu et al. 2026, eLife, DOI 10.7554/eLife.110601).