MYCBPAP

MYCBP associated protein

Ensembl:
ENSG00000136449
UniProt:
Q8TBZ2
OMIM:
609835
Synonyms:
AMAP-1, DKFZP434N1415

Cilia effects upon perturbation of MYCBPAP

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=3.05) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=611, lfc=0.59) PMID:30270045

Ciliopathy associations

  • Male Infertility

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly

Function

Positive staining for motile ciliated cells was observed in the mouse brain, however, ISH staining of ependymal cells lining the choroid plexus in the chickens was only observed in the cases of EFCAB6, FAM183A and MYCBPAP (32616903).

Model organism evidence

Mus musculus (1 reference)

Deletion of Mycbpap led to disrupted centrosome-nuclear envelope docking and abnormal flagellar biogenesis.

PMIDs: 39092789