MYH13

myosin heavy chain 13

Ensembl:
ENSG00000006788
UniProt:
Q9UKX3
OMIM:
603487
Synonyms:
MYHC-EO

Cilia effects upon perturbation of MYH13

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=3.06, ciliated=61.0%) PMID:26595381

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

Immunocytochemistry for proteins encoded by PRKD1, MYO7A, AK9, CWH43, OTOG, NOTCH1, HAVCR1, SPG11, MYH13, and RXFP2 showed increased expression in the ciliated choroid plexus and ventricular ependyma ( 38100419).

Model organism evidence

Mus musculus (1 reference)

Mice homozygous for an iNPH-associated AK9 mutation displayed normal cilia structure and number, but decreased cilia motility and beat frequency, communicating hydrocephalus, and balance impairment.

PMIDs: 38100419