MYO1C

Cilia effects upon perturbation of MYO1C

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.75) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-5.28) PMID:41160700

Subcellular localization

cilia, cytosol, nucleus

References: PMID:11923413

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Viral interactions
• Signaling (Hedgehog, GPCRs, ion channels)

Function

Myo1c binding is modulated by CaM, which implicated the CaM-binding IQ domains in receptor interactions.Myo1c immunoreactivity was also present in the kinocilium, an axonemal cilium located at the tall edge of the hair bundle, and in the kinociliary bulb (11923413).