MYO1D

myosin ID

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000176658
UniProt:
O94832
OMIM:
606539
Synonyms:
KIAA0727, MYR4, PPP1R108

Cilia effects upon perturbation of MYO1D

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.78) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased startle reflex, decreased bone mineral density

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:29769531

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

Myo1D controls the orientation of LRO cilia and interacts functionally with the planar cell polarity (PCP) pathway component VanGogh-like2 (Vangl2), to shape a productive LRO flow. Our findings identify Myo1D as an evolutionarily conserved regulator of animal LR asymmetry, and show that functional interactions between Myo1D and PCP are central to the establishment of animal LR asymmetry ( 29769531).